Constantly feeling fatigued despite getting adequate night's sleep is a clue that your body is fighting off chronic inflammation. Newer evidence links chronic inflammation to chronic fatigue syndrome, depression, and general fatigue. It says, inflammation levels can influence your body, brain, and even your behavior, leading to fatigue. Numerous studies also show that chronically fatigued individuals have significantly higher blood markers of inflammation, such as the protein known as C-reactive protein (CRP) and other pro-inflammatory compounds known as cytokines which are associated with other symptoms such as fatigue following physical exertion, as well as poorer physical performance and poorer self-rated health. Chronic inflammation also plays a central role in diseases like rheumatoid arthritis, cancer, heart disease, diabetes, and even Alzheimer's. Consult your doctor if you have been feeling tired and low on energy for a long time.