Sharp pain in your breast, possibly with some tenderness may need further investigation. Here are a few early signs of breast cancer to watch for. Changes in the shape of the nipple. A new lump that doesnâ€™t go away after your next period. Nipple discharge from one breast that is clear, red, brown, or yellow. Unexplained redness, swelling, skin irritation, itchiness, or rash. Consult experts at our Department of Cancer for diagnosis if you notice any of these symptoms.